You can try adjusting curves in the game under Settings-Controls-(select Hotas on bottom right)- +Flight.
It probably won't help with the scroll wheel cos as far as I understand from
@Ayeteeone that it's only two buttons and not a real Axis.
It may be useful for the thumb stick look mode.
On my Gladiator NXT I use the thumbrest hat switch forw-back on the side of the stick for limiter adjustment and the click-in to toggle Cruise control. It might not be the best for precise fast adjustments in combat but it's very convenient in general.
Also note, on mine the analog thumb stick is treated as a 6 button hat switch by default unless I click it in, then it changes modes to a 2 axis analog stick. Dunno if virpil does this too?
It's currently set up for doing up down and strafing, but I want to set it to look around also as I can't be bothered to set up my webcam and have my lights on for head tracking. I thought I was gonna be fine without looking around until I started playing DCS, now I'm missing it a lot. Sadly the automated head movement in SC is just pure cancer, first thing I do is turn all of it off every patch.