I finally installed Witcher 3 last night (patch 1.04). I am running an AMD FX-6300, Reference R9 290 (OC'd at 1.1Ghz Core, 1.3Ghz mem), 16GB Kingston ValueRAM, and the game is running from a 500GB partition (heavily fragmented) of a Toshiba 1TB HDD.
I started up the game, went into Options ->...