From the game's website here is lil more info on game/story:
Written by Brian Mitsoda, the creative mind behind the original, Vampire: The Masquerade - Bloodlines 2 brings the ambitions of the first to life and sees the return of a few fan favorite characters. Those narrative ambitions are bolstered by Cara Ellison, exploring the effects of the mass embrace on regular Seattleites.
Enter the night as one of several humans inexplicably attacked in a Mass Embrace, suddenly thrown into the dangerous and ruthless vampire politics of Seattle. Tensions between the factions in Seattle are at an all-time high, and this unsanctioned attack throws the status quo into chaos. An inquest is called in order to get to the bottom of the mystery, and you’re the star witness… whether you like it or not..
As one of the few free agents in town, you will choose a side and play an important role in the factional war to control the blood trade. But can your allies answer why you were made, who’s pulling the strings, and who your real enemies are? Or will you be more concerned with what you can do to get ahead among the vampire elite? The choice is yours.