I've been experimenting with two boxing a MOLE, and I think that for the way this thing is setup, it works.
I had an old HOTAS laying around from 10 or so years ago where only the throttle worked, and I've set up my 2nd box so that it uses minimal graphics. I then placed my alt in the primary mining chair. Once I've found a good rock, I start hovering and just mine on my second machine. Last night, I was attacked while mining and was able to instantly switch over to my pilot computer to start trying evasive maneuvers. While I did not manage to escape that time, I think with more experience, I will be able to in the future. If I was solo mining, I would probably have been destroyed before I could exit the mining seat.
Unfortunately, I think this is the ONLY ship where dual boxing...or even triple/quad boxing might be feasible. This is especially true if you have Hofstede or Helix mining heads on all your lasers. Since you only need to use the buffs...or on very rare occasions, provide a slight base power increase, this ship is uniquely set up for multi-boxing in the SC universe. Even if you 4 box, you only need the primary miner to have a good controller for the laser. The rest can just use mouse control as you won't be doing any fine control movements. That said, a full crew would be better.
Last note on the MOLE/Prospector. In the Prospector, I was getting 3...maybe 4k radius on my scans. On my MOLE, I was able to detect some deposits 13k away. This is a huge advantage for the MOLE. If nothing else, when you have a mining expedition, you might want to have a single person going out in a mole to act as a bird dog for deposits and sending the fleet of prospectors out in the right directions.