I must second Mich. The perfect setup is the one you made yourself. Try flying, you will miss some stuff so you figure out what works best for you. You like to fly mixed decoupled, coupled, then you need a fast accessible button for that. You don't like decoupled, forget it and find something which suits you better.
You need pitch yaw on one stick, strafe left/right/up/down or left/right/forward/back on the other stick, just what suits you best. I go for left/right/up/down. It is a personal thing.
Firegroup 1 and firegroup 2 off course, missiles and countermeasures also essential. Shield and power management for the POVs. Targeting also is very important. Don't forget the boost and afterburner. All on the top. You don't want to get hands of stick to do something important.
The 16000 has a lack of buttons on top, so you must make a compromise.