Sounds to me like we might have to put all our eggs in different baskets. Depending on the cost involved, it certainly wouldn't hurt us to put a hanger up in several different locations. So we could have a secure UEE system hanger for our newborn Testies to fly around in, then have a larger base of operations somewhere like Nyx or Odin, and then a trading outpost of sorts at Fora, and then any volunteers capable of a roaming flotilla could establish temporary bases at key locations as they develop. Significant areas can then have a permanent presence established if possible.
This would cover all of our needs but comes at the cost of spreading ourselves out. We'd probably benefit from a good deal of diplomacy to make this work (offer membership to unaffiliated ships in our area of interest, form agreements with neighbouring orgs to not engage within a specific system, keeping our grey activities away from any base of operations - ie, don't shit where we eat).
So long as we focus on the social aspect of the game, there's little to stop an org of our size from carving up several different systems. If, later, we decide we want more power, there's nothing to stop us pushing other orgs out of our systems. Likewise, with a more distributed network it may be easier to move to a new valuable location should one be discovered.
We should still maintain a heavy presence it at least one system, which I still think Nyx is best for, but we should avoid placing all of our firepower in one place. A home base, a trade hub, some roaming flotillas, and a UEE presence should be sufficient if we have the numbers to sustain it.